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KMID : 0615720160330010037
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Jouranl of Korean Acupuncture and Moxibustion society
2016 Volume.33 No. 1 p.37 ~ p.46
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Analgesic Effects of Drosera rotundifolia L. Pharmacopuncture at Taegye(KI3) Acupoint on Formalin-induced Pain
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Oh Se-Jung
Kim Jae-Soo
Lee Yun-Kyu
Lee Hyun-Jong
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Abstract
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Objectives : The objective of this study is to evaluate the analgesic effects of Drosera rotundifolia L. pharmacopuncture on formalin-induced pain in Sprague-Dawley(SD) rats.
Methods : In this experiment there were four groups, each with six SD rats. In the normal group (NOR), normal saline 40 μL was injected at right KI3, and normal saline 40 μL was injected at right hindpaw 35 minutes later. In the control group (CON), normal saline 40 μL was injected at right KI3, and formalin 5 % 40 μL was injected at right hindpaw 35 minutes later. In the Drosera rotundifolia L. pharmacopuncture 3 % group (DP3), Drosera rotundifolia L. pharmacopuncture 3 % 40 μL was injected at right KI3, and formalin 5 % 40 μL was injected at right hindpaw 35 minutes later. In the Drosera rotundifolia L. pharmacopuncture 5 % group (DP5), Drosera rotundifolia L. pharmacopuncture 5 % 40 μL was injected at right KI3, and formalin 5 % 40 μL was injected at right hindpaw 35 minutes later. We analyzed ultrasonic vocalization (USV), Substance P, aspartate aminotransferase(AST), and alanine aminotransferase(ALT).
Results : In the early phase of USV, both DP3 and DP5 had an analgesic effect. In the late phase, DP5 had an analgesic effect compared to CON. Substance P in DP5 was significantly decreased compared to CON. In regards to blood AST and ALT, there was no significant difference among NOR, CON, DP3 or DP5.
Conclusion : These results suggest that Drosera rotundifolia L. pharmacopuncture helps to reduce formalin-induced pain. It's mechanism is related to substance P, and Drosera rotundifolia L. pharmacopuncture has no influence on liver toxicity.
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KEYWORD
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Drosera Rotundifolia L. Phamacopuncture , Analgesic effect , Formalin-induced pain , Taegye(KI3)
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